Cannot open your default e-mail folders. You must connect to Microsoft Exchange with the current profile before you can synchronize your folders with your offline folder file. Steps Taken till now: 1. New outlook profile 2. New Windows profile 3. MaxTokenSize settings in client 4. Tried loading different user logins in these affected machines but same issue & above error 5. HKCU\Microsoft\12.0\Outlook\RPC .......reg fix tried 6. Netsh int ip set chimney DISABLED But nothing solving the issue....Any server Side Check??? What to check in the DNS or how to check that in client machine.....recently i am flooding with calls for the same. NSLOOKUP doing good no error..... But there are lot of machines where user profile not at all loading. If the user tries to login to another machine there is no issue.... Please suggest any other alternative checks Eagerly waiting for the solution.... Manju Gowda

You need to give more detail on your Exchange environment. What version of Exchange? Server distribution? Load Balancer? Have you tried opening the mailbox in OWA?

Dear Russ, Exchange 2007 SP2 with RU10 SCR and 2 standalone servers CAS role is loadbalanced In OWA the mailbox is opening and if the affected users even can opne the outlook in other machines than affected. Regards, ManjuManju Gowda

Hi, Does this issue occur to all the user or only one specific user? You can try ping the Exchange name and see if it succeed. Thanks, Simon

Dear Simon, Ping is fine to the Exchange Server. this happens for the XP SP3 and outlook 2007 comination. If the same user logs into the Windows 7 and Outlook 2010 there is no issue at all ManjuManju Gowda

Hi, Does this issue occur for all the Windows XP + Outlook 2007 clients? Thanks, Simon

Hi All, This is an update. The issue arised due to misconfiguration of a GPO for the perticular OUs. Thank you all for the valuable support. Regards, ManjuManju Gowda